Research Program. Precision Nutrition and Aging

External Supervisor: Dr. Manuel Serrano

Objectives:  This Program is focused on the study of the molecular and physiological effects that nutrition exerts on aging.

Aging is a complex, multi-organ degenerative process, strongly influenced by the genetic background and the environment. Accordingly, this program covers a wide range of biological topics: from the dissection of molecular pathways involved in degenerative pathologies, to the discovery and development of new bioactive products active against agingrelated pathologies, and including nutritional interventions with anti-aging properties, such as periodic fasting or calorie restriction.

Dr. Manuel Serrano

Chair of the Aging and Metabolism Program and Director of the Cellular Plasticity and Disease Group at Institute for Research in Biomedicine (IRB), in Barcelona. External supervisor of the Precision Nutrition and Aging Program of IMDEA

Manuel Serrano is a researcher at the Institute for Research in Biomedicine (IRB), in Barcelona.

After completing his studies and PhD in Madrid, M.S. joined the laboratory of David Beach, at Cold Spring Harbor Laboratory, NY, USA, as postdoctoral fellow from 1992 to 1996. During this time, Manuel Serrano made one of his most important contributions with the discovery of the tumour suppressor p16. Manuel Serrano established his research group, first at the National Center of Biotechnology, Madrid, and since 2003 to 2017 at the CNIO.

The main contributions of the Serrano’s laboratory during these years are related to the concept of oncogene-induced senescence and the anti-aging activity of tumor suppressors. More recently, Serrano’s group has reported on the relevance of tumor suppressors in metabolic Syndrome, the existence of senescence during embryonic development, and the feasibility of embryonic reprogramming within alive adult organisms (the latter was considered “Achievement of the Year 2013” in the stem cells field by Nature Medicine). The unifying theme of Manuel Serrano’s research is to understand and manipulate cellular stress responses in relation to cancer and regeneration.