Research Program. Precision Nutrition and Aging

Nutritional Interventions Group

Group leader: Dr. Rafael de Cabo

Objectives: the Nutritional Interventions Group applies the knowledge gained in model organisms to translate nutritional interventions to improve or delay the decline of function that occurs with aging. We utilize whole body physiological and tissue-specific molecular approaches to investigate effects of nutritional interventions on basic mechanisms of aging and age-related diseases.


Dr. Rafael de Cabo

Chief of the Translational Gerontology Branch, National Institute on Aging (NIH) (USA) Associate researcher, IMDEA Food Group leader of the Nutritional Interventions Group

Rafael de Cabo, PhD is currently the chief of the Translational Gerontology Branch at the National Institute on Aging in Baltimore, Maryland. A nativeof Cordoba, Spain, he received his B.S. from the University of Cordoba, and his Ph.D. in 2000 from the Department of Foods and Nutrition at Purdue University. Upon completion of his graduate education, he trained as a postdoctoral fellow in the Laboratory of Neurosciences at the National Institute on Aging in Baltimore, Maryland. In 2004, he was appointed as a tenure track investigator in the Laboratory of Experimental Gerontology. His group applies both physiological and tissue-specific molecular approaches to investigate effects of nutritional interventions on basic mechanisms of aging and age-related diseases. Research within his unit strives to identify protective mechanisms invoked by caloric restriction and to evaluate the consequences of dietary interventions on lifespan, pathology, and behavioral function. Dr. de Cabo’s research balances the exploration of in vivo rodent, as well as in vitro, paradigms of caloric restriction.