Research Program. Precision Nutrition and Obesity

Nutritional Genomics and Epigenomics Group

Group leader: Prof. José María Ordovás Muñoz

Objectives: our group aims to provide genomic tools and knowledge to manage obesity and
related co-morbidites at the individual level through:

  • The identification of genetic variants predisposing to obesity.
  • The definition of how these variants interact with the diet to modulate such predisposition.
  • The understanding of the dietary modulation of the how diet is able to modulate the obesogenic epigenome.

José María Ordovás Muñoz

Director of the Precision Nutrition and Obesity Program and Group leader of the Nutritional Genomics and Epigenomics Group

José M. Ordovás, PhD, is Professor of Nutrition and Genetics and a Senior Scientist at the USDA-HNRCA at Tufts in Boston, and Director of the Nutrition and Genomics Laboratory. Dr. Ordovás graduated from the University of Zaragoza and did postdoctoral work at the MIT, Harvard and Tufts. He has published over 700 scientific articles in peer review journals (h-index 92) and written numerous reviews and books. In this regard, he is considered one of the most distinguished world experts in gene-diet interactions related to cardiovascular traits. Throughout his career, Dr. Ordovás has received multiple honors for his scientific achievements. He has been awarded an honorary degree in Medicine from the University of Córdoba in Spain and he is Member of the Royal Academies of Sciences, Medicine, Nutrition and Pharmacy. 

Email: jose.ordovas@imdea.org 
Phone: +34 91 727 81 00

Members

Students

Fátima Fernández de la Cerda
Ana Llantada Alamin
José Antonio Celada Guerrero
Verónika Onidi
Lucía Izquierdo Díaz
María Pastor
Cristina Jaén Calvo
Victor Ferrer Sánchez
Ana Mª Sánchez Randulfe
Carmen Fernández Márquez
Javier Tapia Belloso

most relevant publications
  • Canfrán-Duque A, Rotllan N, Zhang X, Fernández-Fuertes M, Ramírez-Hidalgo C, Araldi E, Daimiel L, Busto R, Fernández- Hernando C, Suárez Y. Macrophage defi ciency of miR- 21 promotes apoptosis, plaque necrosis, and vascular infl ammation during atherogenesis. EMBO Mol Med. 2017 Sep;9(9):1244-1262. doi: 10.15252/emmm.201607492.
  • Rosique-Esteban N, Díaz-López A, Martínez-González MA, Corella D, Goday A, Martínez JA, Romaguera D, Vioque J, Arós F, Garcia-Rios A, Tinahones F, Estruch R, Fernández-García JC, Lapetra J, Serra-Majem L, Pinto X, Tur JA, Bueno-Cavanillas A, Vidal J, Delgado-Rodríguez M, Daimiel L, Vázquez C, Rubio MÁ, Ros E, Salas-Salvadó J; PREDIMED-PLUS investigators. Leisure-time physical activity, sedentary behaviors, sleep, and cardiometabolic risk factors at baseline in the PREDIMED-PLUS intervention trial: A cross-sectional analysis. PLoS One. 2017 Mar 8;12(3):e0172253. doi: 10.1371/journal.pone.0172253.
  • Micó V, Martín R, Lasunción MA, Ordovás JM, Daimiel L. Unsuccessful Detection of Plant MicroRNAs in Beer, Extra Virgin Olive Oil and Human Plasma After an Acute Ingestion of Extra Virgin Olive Oil. Plant Foods Hum Nutr. 2016 Mar;71(1):102-8. doi: 10.1007/s11130-016-0534-9.
  • Blanco-Rojo R, Delgado-Lista J, Lee YC, Lai CQ, Perez- Martinez P, Rangel-Zuñiga O, Smith CE, Hidalgo B, Alcala-Diaz JF, Gomez-Delgado F, Parnell LD, Arnett DK, Tucker KL, Lopez-Miranda J, Ordovas JM. Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries. Am J Clin Nutr. 2016 Aug;104(2):508-17. doi: 10.3945/ajcn.116.130898. Epub 2016 Jul 20.
  • Aslibekyan S, Demerath EW, Mendelson M, Zhi D, Guan W, Liang L, Sha J, Pankow JS, Liu C, Irvin MR, Fornage M, Hidalgo B, Lin LA, Thibeault KS, Bressler J, Tsai MY, Grove ML, Hopkins PN, Boerwinkle E, Borecki IB, Ordovas JM, Levy D, Tiwari HK, Absher DM, Arnett DK. Epigenome-wide study identifi es novel methylation loci associated with body mass index and waist circumference. Obesity (Silver Spring). 2015 Jul;23(7):1493-501. doi: 10.1002/oby.21111.
main research grants

Principal Investigator: Lidia Daimiel Ruiz
Project Title: PREDIMED+DM: Effect of a hypocaloric Mediterranean diet and physical activity promotion on the prevention of type 2 diabetes mellitus in subjects with the Metabolic Syndrome
Date: 2018-2020
Funded by: Instituto de Salud Carlos III (PI17/000508)

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Participant Investigator: Jose María Ordovás Muñoz
Project Title: Interindividual variation in response to consumption of plant food bioactives and determinants involved (COST Action-POSITIVe)
Date: 2014-2018
Funded by: European Union 7th Framework Program. European Cooperation in Science and Technology (COST Action FA 1403)

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Participant Investigator: Jose María Ordovás Muñoz
Project Title: Application of new technologies and tools to nutrition research-the example of phenotypic flexibility (NUTRITECH)
Date: 2011-2016
Funded by: European Union 7th Framework Program. (FP7- KBBE-2011-5)

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Participant Investigator: Jose María Ordovás Muñoz
Project Title: Effect of extra virgin olive oil on plasma miRNA levels in healthy subjects: a postprandial study. Association with the cardiovascular benefi ts associate to olive oil intake. Detection of exogenous miRNAs
Date: 2013-2015
Funded by: Fundación Salud 2000

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Principal Investigator: Jose María Ordovás Muñoz
Project Title: Effect of beer consumption on circulating levels of microRNAs in relation to cardiovascular disease. Beer exogenous microRNAs as cardiovascular health effectors (micRoBeer)
Date: 2014-2015
Funded by: Fundación Cerveza y Salud

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