Research Program. Precision Nutrition and Cancer

Molecular Oncology Group

Group leader: Dr. Ana Ramírez de Molina

Objectives: The group is currently focused on two research topics:

  • Lipid metabolism alterations in cancer: identifi cation of new biomarkers and therapeutic targets in diet-related tumors such as colon or pancreatic cancer. 

  • We are especially interested in identifying metabolic profi les associated to the disease progression and analyzing their role from in-vitro cell systems to organoids and cancer patients. These analyses are mainly focused on the identifi cation of metabolic pathways and distinctive oncometabolites that may constitute novel markers and targets for the development of future cancer therapies, as well as the genetic basis of the relationship between obesity, associated metabolic disorders and cancer. 

  • Activity and mechanism of action of bioactive compounds as potential effective dietary supplements in cancer prevention and treatment. 

  • We evaluate the activity and molecular mechanism of action of bioactive compounds that may have a therapeutic use in cancer, either alone or in combination with existing chemotherapy. The aim is to establish the scientifi c basis for the development of nut.


Dr. Ana Ramírez de Molina

Deputy Director, Director of the Precision Nutrition Program and Group leader of the Molecular Oncology Group.

Dr. Ana Ramírez de Molina has developed her scientific career in the field of lipid metabolism, molecular oncology, nutrition and cancer. She has worked as an associated researcher in the Traslational Oncology Unit CSIC-UAM-La Paz Hospital (Madrid), and has performed long postdoctoral stays at Cancer Research UK Centre for Therapeutics (London) and the Molecular Pathology Division of the Sloan Kettering Cancer Center (New York). She has published more than 60 scientific articles in her research field, is co-inventor of 6 patents in different phases of exploitation by a biotechnology company and has supervised 6 PhD Thesis.

Several of her patents promoted the creation of a spin-off company from CSIC focused on the development of new tumour markers and therapies in Cancer in which she was former Director of Research, Development and Innovation for more than 3 years. She joined IMDEA Food Institute in 2010, where she leads the Programe of Precision Nutrition and Cancer. From 2011 she has been the Coordinator of Research, Development and Transfer, and in 2014 was promoted to Deputy Director of the Institute.

In 2002 she was awarded with the prize Young Researchers MSD, in 2003 the extraordinary doctorate recognition as the best Thesis of her promotion in Molecular Biology, and in 2016 the 8th March distinction from the Community of Madrid as an outstanding woman in Science.

Email: ana.ramirez@imdea.org
Phone: +34 91 727 81 00, ext. 102


Members

Students

Jesús del Barrio Morán
Marta Luengo Redondo
David Menchen
Laura Pietrantonio
Liz Alejandra Ponce Morales
Amanda Sousa Ruz
Pablo Mata Martínez
Paula Cortés Torres
Lidia Yamile Jiménez Batista
Pablo Mata Martínez
Ester Sánchez Martín
Ester Díez Sáinz
Sara Gutiérrrez Pelaz
Claudia Flavia García Martín


most relevant publications
  • Cruz-Gil S, Sanchez-Martinez R, Gomez de Cedron M, Martin- Hernandez R, Vargas T, Molina S, Herranz J, Davalos A, Reglero G, Ramirez de Molina A. J Targeting the metabolic axis ACSL/SCD in colorectal cancer progression by therapeutic miRNAs: miR-19b-1 role. Lipid Res. 2018 Jan;59(1):14-24.
  • Fernández LP, Ramos-Ruiz R, Herranz J, Martín-Hernández R, Vargas T, Mendiola M, Guerra L, Reglero G, Feliu J, Ramírez de Molina A. The transcriptional and mutational landscapes of lipid metabolism-related genes in colon cancer. Oncotarget. 2017 Dec 21;9(5):5919-5930.
  • Gómez de Cedrón M, Acín Pérez R, Sánchez-Martínez R, Molina S, Herranz J, Feliu J, Reglero G, Enríquez JA, Ramírez de Molina A. MicroRNA-661 modulates redox and metabolic homeostasis in colon cancer. Mol Oncol. 2017 Dec;11(12):1768-1787. doi: 10.1002/1878-0261.
  • Sánchez-Martínez, Cruz-Gil S2, García-Álvarez MS, Reglero G, Ramirez de Molina A. Complementary ACSL isoforms contribute to a non-Warburg advantageous energetic status characterizing invasive colon cancer cells. Scientific Reports. 2017 Sep 11;7(1):11143.
  • Aguirre-Portolés C, Fernández LP, Ramírez de Molina A. Precision Nutrition for Targeting Lipid Metabolism in Colorectal Cancer. Nutrients. 2017 Sep 28;9(10). Cover .
main research grants

Principal Investigator: Ana Ramírez de Molina
Project Title: Formulacion de productos alimentarios para la prevencion y el tratamiento Dirigido de enfermedades crónicas relacionadas con el metabolismo. (FORCHRONIC)
Date: 2016-2019
Funded by: Ministerio de Economía y Competitividad.Programa Estatal de investigación, desarrollo e innovación orientada a los retos de la sociedad (AGL2016-76736-C3-3-R)

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Principal Investigator: Ana Ramírez de Molina
Project Title: Estrategias para promocionar la calidad de vida de pre-seniors y seniors basadas en la Nutrición de Precisión (NUTRIPRECISIÓN)
Date: 2017-2020
Funded by: Centro para el Desarrollo Tecnológico Industrial (CDTI). Ministerio de Economía y Competitividad (CDTI IDI 20141213)

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Principal Investigator: Ana Ramírez de Molina
Project Title: Alimentos funcionales y estrategias nutricionales eficaces para la prevención y tratamiento de enfermedades crónicas (ALIBIRD III)
Date: 2014-2018
Funded by: Consejería de Educación e Investigación. Comunidad de Madrid (ALIBIRD III P2013/ABI-2728)

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Principal Investigator: Guillermo Reglero Rada and Ana Ramírez de Molina
Industrial coordinator: Galletas Gullón S.A.
Project Title: Personalización de la nutrición para llevar al mercado alimentos de alta eficacia (PRIMICIA)
Date: 2015-2017
Funded by: Programa CIEN, Centro para el Desarrollo Tecnológico Industrial. Ministerio de Economía y Competitividad

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