Research Program. Precision Nutrition and Cancer

Molecular Immunonutrition Group

Group leader: Dr. Moisés Laparra Llopis

Objectives: Immunonutritional-based precision intervention strategies to selectively modulate innate immune responses preventing/treating the risk for severity of diseases affecting the gut-liver axis.

Understanding of how tolerance and immunity regulate antitumoral responses, among other, this project aims at elucidating innate cell biology as a path forward to develop durable, long-lasting immune responses.

To defi ne the extent to which immunonutritional-based modulation can be translated into physiological benefits within the neuro-immunometabolic axis.

Dr. Moisés Laparra Llopis

Group leader of the Molecular Immunonutrition Group

José Moisés Laparra Llopis holds a PhD in Pharmacy gained during his stay at the High Research Council of the Spanish Government. His scientific career is focused on the field of intestinal homeostasis and the crosstalk within gut-liver axis. The novelty and scientific and social impact of his studies was used by the European Food Safety Authority to establish recommendations concerning staple foods. A continuous contact and interaction with internationally renowned research groups constitutes a constant in Dr. Laparra’s career. He held a leading position on prebiotic research awarded by The Fulbright Commission to conduct postdoctoral research in the Food Science Department at Cornell University.

Additionally, he participated in teaching activities that end up in a renowned honor thesis awarded by the professional organization for food science and technology professionals in the U.S. This experience favored his incorporation to the Institute of Translational Immunology at the University Medical Center of Mainz University as independent researcher. Dr. Laparra has published over 70 scientific articles and book chapters.

He has overseen several precompetitive public funded projects. As senior researcher at IMDEA Food he develops immunonutritional-based precision strategies to tumor suppressioner.

Email:  moises.laparra@imdea.org
Phone: +34 91 727 81 00, ext. 213

 

Members

Visiting researchers

Dr. Bartosz Fotschki
Polish Academy of Sciences

Students

Lorena Alejandra Lee Pellecer
Sandra Lozano Pacual
Angela Mera
Sara Vivas
Laura Lorente Romeral
Nuria Zalckwar Diment
Lucía Martínez Carreras

 

most relevant publications
  • Kaliszewska A, Martinez V, Laparra JM. Proinflammatory responses driven by non-gluten factors are masked when they appear associated to gliadins. Food Chem Toxicol. 2016, 95:89-95.
  • Alemany L, Barbera R, Alegría A, Laparra JM. Plant sterols from foods in inflammation and risk of cardiovascular disease: a real threat? Food Chem Toxicol. 2014, 69:140-9.
  • Laparra JM, Olivares M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 ameliorates gliadininduced alterations in liver iron mobilisation. Br J Nutr. 2013, 110(10):1828-36.
  • Olivares M, Laparra M, Sanz Y. Oral administration of Bifidobacterium longum CECT 7347 modulates jejunal proteome in an in vivo gliadin-induced enteropathy animal model. J Proteomics. 2012, 77:310-20.
  • Laparra JM, Vélez D, Barberá R, Farré R, Montoro R. Bioavailability of inorganic arsenic in cooked rice: practical aspects for human health risk assessments. J Agric Food Chem. 2005, 53(22):8829-33.
main research grants

Principal Investigator: Moisés Laparra Llopis
Project Title: Molecular immunonutrition of the metabolic dysfunction and antitumoral response
Date: 2016–2021
Funded by: Ministerio de Economía y Competitividad. Ayudas para contratos Ramón y Cajal (RYC-2015-18083)

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Principal Investigator: Mónica Haros
IMDEA Food participant investigator:Moisés Laparra Llopis
Project Title: Development of novel ingredients from Quinoa and Chia for food formulation: Evaluation of Nutritional and health features
Date: 2016–2019
Funded by: Ministerio de Economía y Competitividad. Programa Estatal De Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (AGL2016-75687-C2-1-R)

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Principal Investigator: Lisardo Bosca Gomar (UCM)
IMDEA Food participant investigator:Moises Laparra Llopis
Project Title: Consortium for the study of acute renal dysfunction: physiopathology, novel therapies, biomarkers and experimental models
Date: December 2017
Funded by: Consejería de Educación e Investigación. Comunidad de Madrid (B2017/BMD-3686)

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