Research Program. Precision Nutrition and
Cardiometabolic Health

Epigenetics of Lipid Metabolism Group

Group leader: Dr. Alberto Dávalos Herrera

Objectives: cardiometabolic diseases are the main causes of mortality in the world and excess in the diet is one of the main causes of these human diseases linked to our modern life-style. The objective is to understand how different non-coding RNAs regulate lipid metabolism during states of health and disease, developing new strategies, both pharmacological and dietetic, to modulate their function. Pharmacological or dietary modulation of the activity of non-coding RNAs that, ultimately, regulate the metabolism of lipids lead to the prevention or treatment of cardiometabolic diseases. The increasing prevalence of chronic diseases has prompted a strategic focus on prevention strategies. While Precision (personalized) Medicine strives to provide ‘the right therapeutic strategy for the right person at the right time’ a distinct approach is needed for disease prevention.

Epigenetics of Lipid Metabolism Group also focus on understanding lifestyle modification of the pigenome in order to try to personalize the health of individuals using epigenetics for the development of Precision Nutrition. This group works to generate new basic knowledge of how non-coding RNAs regulate the metabolism of lipids under physiological and pathological conditions. To find and evaluate minor dietary components for their ability to modulate the activity of non-coding RNAs associated with the metabolism of lipids.

To carry out collaborative projects with the food and pharmaceutical industry to test and develop new dietary supplements or functional foods based on solid scientific knowledge to prevent or treat a variety of lipid metabolism disorders. And, to incorporate the use non-coding RNAs data to develop Precision Nutrition. In this endeavor, the group actively collaborate with many international research groups located at the following institutions: CINVESTAV (Mérida, Mexico), URFJ (Rio de Janeiro, Brasil), IMSERM UMR1011 (Lille, France) and many other national research groups. 

Dr. Alberto Dávalos Herrera

Group leader of the Epigenetics of Lipid Metabolism Group

Dr. Alberto Dávalos holds a degree in Pharmacy and Biochemistry by San Marcos University (Lima) and a PhD in Pharmacy by Universidad Complutense de Madrid (Madrid). He has conducted postdoctoral research at the Hospital Ramón y Cajal (Madrid), at Yale University School of Medicine, (New Haven), and at New York University School of Medicine (New York). Dr. Dávalos’s research program focuses in identifying and characterizing new noncoding RNAs (miRNAs, lncRNAs and other type of regulatory RNAs) that regulate lipid metabolism and the effects of minor dietary components (micronutrients) on their expression.

Noncoding RNAs have been recognized as critical modulators of cardiovascular system in health and disease. He hopes to: (i) identify new therapeutic strategies through modulating noncoding RNAs levels by the diet or other lifestyle factors to treat dyslipidemia and to prevent atherosclerosis and cardiovascular diseases; and (ii) understand lifestyle modification of the epigenome and personalize the health of individuals using epigenetics (particularly noncoding RNAs) for the development of Precision Nutrition.

Email: alberto.davalos@imdea.org
Phone: +34 91 727 81 00, ext. 206 

Members

Visiting researches

Visiting researches:
Flavia Brasil Spreafico
University of Rio de Janeiro


Students

Yolanda Molero Miguel
Ainoa Gómez Díaz