Research Program. Precision Nutrition and Cancer

Computational Biology

Group leader: Dr. Enrique Carrillo de Santa Pau

Objectives: Our group aims to develop and apply integrative bioinformatic analyses to study the impact of nutritional behaviours on health and complex diseases (cancer, cardiovascular diseases,…). Bioinformatics will help us to understand the complexity of the relationships between food, genes and disease, which will allow establishing precision personalized nutrition strategies based on individual molecular background. Our research is focused on:

  • The development of bioinformatic tools to integrate large genomic, epigenomic and clinical datasets
  • The study of nutrition imprinting in healthy and disease status at genomic, epigenomic and transcriptomic levels
  • The application of molecular knowledge acquired into precision personalized nutrition strategies

Dr. Enrique Carrillo de Santa Pau

Group leader of the Computational Biology Group

Dr. Enrique Carrillo de Santa Pau, obtained his Bachelor’s degree (BSc) at the “Complutense” University (Madrid) in 2002. He completed a PhD training program (2002-2007) in Biochemistry and Molecular Biology at “Ramón y Cajal” Hospital. In 2007, he moved at Primary Health Care Service in Madrid to study Diabetes Mellitus as part of MADIABETES. He got an MsC in Bioinformatics and Computational Biology (UCM, 2009). In 2010 he joined Dr. Stunnenberg’s group at Nijmegen Centre for Molecular Life Sciences (The Netherlands) to study the role of 5hmC from a genome wide perspective. In 2011, he moved at Spanish National Cancer Research Centre (CNIO) where he was responsible for the bioinformatic analyses at the Carcinogenesis Epithelial Group lead by Dr. F.X. Real. In addition, he participated in the analysis of large-scale ‘omic’ datasets from the EU high impact initiative: “BLUEPRINT of Haematopoietic Epigenomes”, within Dr. A. Valencia’s group. From April 2018 he joined IMDEA Food Institute to lead the Computational Biology Group.


Phone: +34 91 727 81 00, ext. 304


most relevant publications
  • Isidoro Cobo; Paola Martinelli; Marta Flandez; Latifa Bakiri; Mingfeng Zhang; Enrique Carrillo-de-Santa-Pau; Jinping Jia; Liv Thommesen; Torunn Bruland; Natalia del Pozo; et al. Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas. Nature. 10.1038/nature25751, Nature Publishing Group, 2018. Available on-line at:
  • Enrique Carrillo-de-Santa-Pau*; David Juan*; Vera Pancaldi; Felipe Were; Ignacio Martin- Subero; Daniel Rico; Alfonso Valencia; BLUEPRINT Consortium. Automatic identification of informative regions with epigenomic changes associated to hematopoiesis. Nucleic acids research. 45 - 16, pp. 9244 - 9259. Oxford University Press, 2017. *Co-First authors
  • David Juan*; Juliane Perner*; Enrique Carrillo de Santa Pau*; Simone Marsili*; David Ochoa; Ho-Ryun Chung; Martin Vingron; Daniel Rico; Alfonso Valencia. Epigenomic co-localization and co-evolution reveal a key role for 5hmC as a communication hub in the chromatin network of ESCs. Cell reports. 14 - 5, pp. 1246 - 1257. Cell Press, 2016. *Co-First authors
  • Vera Pancaldi; Enrique Carrillo-de-Santa-Pau; Biola Maria Javierre; David Juan; Peter Fraser; Mikhail Spivakov; Alfonso Valencia; Daniel Rico. Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity. Genome biology. 17 - 1, pp. 152 - 152. BioMed Central, 2016.
  • Laia Richart; Enrique Carrillo-de Santa Pau; Ana Río-Machín; Mónica P De Andrés; Juan C Cigudosa; Víctor J Sánchez-Arévalo Lobo; Francisco X Real. BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis. Nature communications. 7, pp. 10153 - 10153. Nature Publishing Group, 2016.
main research grants

Participant Investigator: Enrique Carrillo de Santa Pau
Project Title: Estudio de cohortes sobre la morbilidad cardiovascular y mortalidad de sujetos con diabetes T2 conocida y no conocida, prediabetes y normoglucemia
Date: 2015-2019
Funded by: Ministerio de Sanidad y Consumo. Fondo de Investigación Sanitaria (PI1500259)


Participant Investigator: Enrique Carrillo de Santa Pau
Project Title: BLUEPRINT – A BLUEPRINT of Haematopoietic Epigenomes
Date: 2011-2016
Funded by: 7th Framework Programme for Research and Technological Development of the European Commission (FP7/ No282510)