Research Program. Precision Nutrition and Cancer

Computational Biology

Group leader: Dr. Enrique Carrillo de Santa Pau

Objectives: Our group aims to develop and apply integrative bioinformatic analyses to study the impact of nutritional behaviours on health and complex diseases (cancer, cardiovascular diseases,…). Bioinformatics will help us to understand the complexity of the relationships between food, genes and disease, which will allow establishing precision personalized nutrition strategies based on individual molecular background. Our research is focused on:

  • The development of bioinformatic tools to integrate large genomic, epigenomic and clinical datasets
  • The study of nutrition imprinting in healthy and disease status at genomic, epigenomic and transcriptomic levels
  • The application of molecular knowledge acquired into precision personalized nutrition strategies

In addition, the group is active in the TransBioNet (Spanish National Bioinformatic Institute), FNS-Cloud networks and COST Action CA18131 (“Statistical and machine learning techniques in human microbiome studies”). The group members participate in innovation and education activities of EIT Food, like WeLead, AnnualFoodAgenda or MakeIT, being responsible for organizing the Madrid Summer School of the Global Food Venture Program -EIT Food for future food entrepreneurs.

Dr. Enrique Carrillo de Santa Pau

Group leader of the Computational Biology Group

Dr. Enrique Carrillo de Santa Pau, obtained his Bachelor’s degree (BSc) at the “Complutense” University (Madrid) in 2002. He completed a PhD training program (2002-2007) in Biochemistry and Molecular Biology at “Ramón y Cajal” Hospital. In 2007, he moved at Primary Health Care Service in Madrid to study Diabetes Mellitus as part of MADIABETES. He got an MsC in Bioinformatics and Computational Biology (UCM, 2009). In 2010 he joined Dr. Stunnenberg’s group at Nijmegen Centre for Molecular Life Sciences (The Netherlands) to study the role of 5hmC from a genome wide perspective. In 2011, he moved at Spanish National Cancer Research Centre (CNIO) where he was responsible for the bioinformatic analyses at the Carcinogenesis Epithelial Group lead by Dr. F.X. Real. In addition, he participated in the analysis of large-scale ‘omic’ datasets from the EU high impact initiative: “BLUEPRINT of Haematopoietic Epigenomes”, within Dr. A. Valencia’s group. From April 2018 he joined IMDEA Food Institute to lead the Computational Biology Group.

Phone: +34 91 727 81 00, ext. 304