Research Program. Precision Nutrition and
Bioactive Ingredients Food Group
Objectives: the Bioactive Ingredients Food Group is being developing a Ministry of Innovation (MICINN) – funded study on the effects of selected phospholipids in models of aging and cognitive decline. In particular, the group is investigating the nutrigenomic effects of phospholipids isolated from buttermilk and krill oil, via innovative technologies developed in the CIAL (UAM + CSIC Madrid campus). Aging represents an important socio-economic issue, in that the European population is rapidly aging and the health care costs associated with this demographic phenomenon are becoming unbearable. Therefore, there is a strong need to find suitable and effective preventive measures, to lessen the burden of disease and decrease budgetary stress. In particular, aging is associated with cognitive decline, which can become severe and develop into dementia and/or Alzheimer’s disease.
Given than the brain is the organ richest in lipids (up to 40% in weight), the LabFun thinks it conceivable to supply appropriate phospholipids to maintain and/or restore proper membrane composition, fluidity, and signal transduction. The preliminary results do demonstrate the provision of food-derived phospholipids (formulated through original techniques) are able to ameliorate the synaptic machinery and restore adequate mitochondrial function. The group employs in vitro and in vivo (including human) approaches to create strong and solid scientific data and foster the formulation of evidence-based nutraceuticals and functional foods. In addition, the group keeps publishing the results of former projects along with reviews on specific topics, therefore enjoying a strong publication record.
Dr. João Tiago Estevao Tomé Carneiro
The research carried out by Dr. Joao Tiago Estevao Tomé Carneiro has been focusing on the biological activity of food constituents in chronic pathologies. He has a degree in biochemistry and he obtained his PhD at the University of Murcia working at CEBAS-CSIC (2013). He is the co-author of 15 peer-reviewed papers in relevant international journals. In 2014, hejoined the Bioactive Ingredients Food Group at IMDEA Food, where he contributes to the assessment of the potential health effects of bioactive food components in vitro, in vivo and through placebo-controlled randomized clinical trials.
He is currently participating in a research project focused on evaluating if the consumption of bioactive phospholipids, as part of a nutritional supplement, contributes to the improvement or delaying of mild cognitive impairment and its correlation with different biological, clinical or neuropsychological biomarkers.
Phone: +34 91 727 81 00, ext. 205
Carmen Crespo Lorenzo
Mª del Carmen Crespo Lorenzo has a degree in Molecular and Cellular Biology from the IE University of Segovia (2010). In 2013 she obtained a Master degree in pharmacological research from the UAM. As part of her research activity, she was part of the research project team “Genetic and genomic analysis in patients affected by Gorham-Stout Disease and General Lymphatic Anomalies” at the Hospital Universitario La Paz. In June 2014, she began her Ph.D. program at IMDEA’s Bioactive Ingredients Food Group.
She is playing a relevant part in nutrigenomic and epigenetic projects with different micronutrients (e.g.Hydroxytyrosol, bioactive phospholipids) performing in vitro, in vivo and placebo-controlled, randomized trials in healthy volunteers to evaluate the possible beneficial effect that these molecules play on chronic diseases and find their molecular targets, in order to find new therapeutic strategies. Her publication record shows 10 papers.
Phone: +34 91 727 81 00 , ext. 205
León Gema Bastante del Palacio
Jorge Llanos Garrido
María Trapero Ruiz
Beatriz Castro Meco
Sara Rollan Esteban