Research Program. Precision Nutrition and Aging

Director: Dr. Manuel Serrano Marugán

Objectives:  the recently created Precision Nutrition and Aging Program at IMDEA Food is focused on the molecular and physiological effects that nutrition exerts on the process of aging. Since aging is a complex, multi-organ degenerative process strongly influenced by the genetic background and the environment, our research covers a wide range of biological topics: from the discovery and development of new bioactive products active against aging-related pathologies, to the dissection of different molecular pathways involved in degenerative pathologies, or the study of nutritional interventions with anti-aging properties, such as fasting or calorie restriction.

Headed by Dr. Manuel Serrano, one of the most prestigious Spanish scientist in the fields of aging and cancer, the Precision Nutrition and Aging Department is intensely expanding at the moment. Recently, it has incorporated another of the worldwide best-known aging scientist, Dr. Rafael de Cabo, from the National Institute of Aging, a reference in the study of calorie restriction as a nutritional intervention to lengthen lifespan. Along with these two very important figures, the group of Dr. Pablo J. Fernandez-Marcos, focused on nutritional interventions (bioactive products, fasting) to fight obesity, diabetes and aging, form the program. 

Dr. Manuel Serrano Marugán

Director of the Tumour Suppression Group and Director of the Molecular Oncology Program, Spanish National Cancer
Research Center Associate researcher, IMDEA Food Director of the Precision Nutrition and Aging Program

Manuel Serrano is a researcher at the Spanish National Cancer Research Centre (CNIO), in Madrid, and Director of the Molecular Oncology Program of the CNIO.

After completing his studies and PhD in Madrid, M.S. joined the laboratory of David Beach, at Cold Spring Harbor Laboratory, NY, USA, as postdoctoral fellow from 1992 to 1996. During this time, Manuel Serrano made one of his most important contributions with the discovery of the tumour suppressor p16. Manuel Serrano established his research group, first at the National Center of Biotechnology, Madrid, and since 2003 at the CNIO.

The main contributions of the Serrano’s laboratory during these years are related to the concept of oncogene-induced senescence and the anti-aging activity of tumor suppressors. More recently, Serrano’s group has reported on the relevance of tumor suppressors in metabolic Syndrome, the existence of senescence during embryonic development, and the feasibility of embryonic reprogramming within alive adult organisms (the latter was considered “Achievement of the Year 2013” in the stem cells field by Nature Medicine). The unifying theme of Manuel Serrano’s research is to understand and manipulate cellular stress responses in relation to cancer and regeneration.