Research projects > Competitive Research Projects


Developing products for personalized nutrition of gastric cancer patients

Principal investigator: Dr. Ana Ramírez de Molina
Funded by: Ministerio de Economía y Competitividad Duration: 2014 - 2016

FORCANCER project aims to exploit the opportunities offered by the current state of knowledge to design and validate effective food products to improve some aspects of cancer. Its objectives are to obtain and characterize functional food ingredients of high bioavailability, combining natural extracts rich in phenolic compounds with alkylglycerols and glycerides as carrier lipids to formulate nutritional supplements and functional foods aimed at reducing the rate of tumor progression and to improve the general condition and response to treatment of colon and pancreatic cancer patients.

European Projects Bureau MADRIMASD - IMDEA Food

Funded by: Ministerio de Economía y Competitividad
Duration: 2014 - 2016

The European Research Projects Office is an initiative to promote researchers’ participation in European funding programs. The project is made up of the following institutions: IMDEA Water, IMDEA Food, IMDEA Energy, IMDEA Materials, IMDEA Nanoscience, IMDEA Networks, IMDEA Software and Madri+d Foundation, which coordinates the project. The European Research Projects Office is responsible for giving support in the application, giving expert advice in project management and informing researchers about funding opportunities.


Functional Foods and nutritional strategies for the prevention and treatment of chronic diseases. (ALIBIRD III S2013/ABI-2728)

Principal investigators: Dr. Ana Ramírez de Molina (ONCOGENOM) and Dr. Francesco Visioli (GENECO)
Funded by: Consejería de Educación, Juventud y Deporte. Comunidad de Madrid
Duration: 2014 - 2018

A total of 9 research groups of the Community of Madrid are involved in this consortium that aims to advance forward scientific aspects of knowledge needed for the development of high efficacy and security functional foods to contribute to the improvement of the health of populations, and reducing obesity and improving the life of cancer patients. It also pretends to contribute to the competitiveness of European industry in the food and nutrition area.


Effect of a hypocaloric Mediterranean Diet and physical activity promotion on the prevention of type 2 diabetes mellitus in subjects with the Metabolic Syndrome

Principal investigator: Dr. Lidia Daimiel Ruiz
Funded by: Instituto de Salud de Carlos III
Duration: 2015 - 2017

The aim of this project is to evaluate the effect on the incidence of T2DM of an intensive weight loss intervention based on a traditional hypocaloric Mediterranean Diet, physical activity and behavioural therapy, as compared to dietary advice based on a Mediterranean Dietary in the context of usual health care. The PREDIMED+DM study is impinged in the PREDIMED-PLUS study, a randomized clinical trial evaluating the effect of same therapeutic strategies used in our study but on primary prevention of cardiovascular disease in overweight/obese subjects with the metabolic syndrome. 


Evaluation of a nutritional supplement enriched with bioactive phospholipids designed to prevent age-associate mild cognitive impairment

Principal investigator: Dr. Javier Fontecha Alonso (CIAL, CSIC-UAM) IMDEA Food participant investigator: Dr. Francesco Visioli
Funded by: Ministerio de Economía y Competitividad
Duration: 2015 - 2018

Cognitive impairment (IC) associate with age (Age-related cognitive decline -ARCD) is one of the great challenges of our society today due to the aging population, which is a serious social and family problem, as well as a great difficulty for national health systems. Since currently available pharmacological treatments are not effective in preventing IC, are been promoted multidisciplinary strategies related to the prevention of chronic diseases associate with aging. Both the R+D+I and the H2020 include multidisciplinary lines in order to improve the understanding, prevention, early diagnosis and treatment of mental condi- tions and disorders of the elderly.

PHOSPHOLIPIDS4COGNITION raises the approach of a coordinated multidisciplinary project, whose overall objective is to investigate the effect of the intake
of PLs bioactives (of dairy and marine origin) in the prevention and treatment of cognitive impairment associate with aging, using a preclinical study with aged rats and a clinical study in a cohort of older adults previously diagnosed with mild cognitive impairment. 


Formulation of food products for the prevention and targeted treatment of chronic diseases related to metabolism (AGL2016-76736-C3-3-R)

Principal investigator: Dr. Ana Ramírez de Molina
Funded by: Ministerio de Economía y Competitividad
Duration: 2016 - 2019

The objective of the project FORCHRONIC is to design, develop and validate the effect and safety of new formulas for humans, effective in regulating the molecular mechanisms of cellular cholesterol transport and the activation of fatty acid synthesis, fundamental routes in the development of colorectal cancer, obesity and metabolic syndrome, in order to achieve food products with high added value, highly effective as nutritional supplements aimed at preventing and improving the treatment of these diseases.

The project is based on two hypotheses resulting from the previous project carried out by the research team within the State Program of R+D+I, Challenging the Society; The regulation of ABCA1 metabolism genes and the ACSL / SCD pathway allows the control of cholesterol transport pathways and the activation of fatty acid synthesis, associated with the development of chronic diseases such as colon cancer and the metabolic syndrome; Formulas based on the combination of polar lipids and bioactive principles of natural origin can provide for efficient regulation of metabolism genes due to potentiation of bioavailability and synergistic biological activity. 


Therapeutic modulation of non-coding RNAs through bioactive components of the diet: impact on pathophysiological regulation of lipid metabolism (AGL2016-78922-R)

Principal investigator: Dr. Alberto Dávalos Herrera
Funded by: Ministerio de Economía y Competitividad
Duration: 2016 - 2019

Despite advances in the prevention and the success of many widely prescribed drugs for the anagement of dyslipidemia, cardiovascular disease remains a leading cause of mortality. This highlights the need for deeper insight into disease mechanism and innovative therapeutic strategies. A large amount of novel transcripts from our genome are transcribed into different types of noncoding RNAs (ncRNAs) including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). Several novel ncRNAs are being identified as regulators of different biological processes and associated with different complex human diseases. Moreover, recent evidence suggests that the expression of certain miRNAs and lncRNAs can be modulated by food bioactive components.

The emerging function of ncRNAs in cholesterol and lipid metabolism and their possible modulation by diet, open up new therapeutic possibilities. “Intesti-NahRuNg” aims to characterize the role of novel miRNAs and lncRNAs in both the physiological and pathological processes of intestinal lipid metabolism and test their therapeutic modulation through dietary bioactive compounds. 


Formulation of food products for the prevention and targeted treatment of chronic diseases related to metabolism (AGL2016-76736-C3-3-R)

Principal investigator: Dr. Pablo Fernández Marcos
Funded by: Fundación BBVA
Duration: 2016 - 2018

Obesity and the pathologies derived, encompassed under the term Metabolic Syndrome, are considered one of the main health challenges of the 21st century. Many naturally occurring extracts have been used against obesity and diabetes for centuries, in many cases with beneficial effects and few side effects, and almost always without a thorough knowledge of their mechanisms of action.

The NUPROBED project, which is being carried out by IMDEA Food in collaboration with the Institute of Food Science Research (CIAL) and the National Cancer Research Center (CNIO), aims to find new bioactive products derived from foods with potential against Obesity, thanks to its effects on the main metabolic signaling pathways involved in this pathology. This project contemplates conducting a bioactive product search through high performance biological research platforms (HTS) testing four crucial metabolic pathways for obesity and diabetes: Insulin pathway, mitochondrial potential, pentoses phosphate pathway and adipogenesis.


Population, family and aging in the contemporary world: dimensions of an ongoing process (S2015/HUM-3321)

Principal investigator: Dr. David Sven Reher Sullivan (UCM)
IMDEA Food participant investigator: Dr. Lidia Daimiel Ruiz
Funded by: Consejería de Educación, Juventud y Deporte. Comunidad de Madrid
Duration: 2016 - 2018

The Project GEPS: “Population, family and aging in the contemporary world: different dimensions of an ongoing process” is root in the Social Sciences sphere but with the purpose of gathering professionals from the Health Sciences and the Social Sciences to study different aspects of the aging process. In the frame of this project, different studies will be carried out that focus on:

  • Fertility and reproduction
  • International migrations and demographic shift
  • Family · Economic challenges associated with the aging society
  • Active life in elder people
  • Nutrition and quality of live in the aging process

This project offers a multidisciplinary study of aging process from a historical, demographic, sociological, economical and biological point of view. As a result, this project will allow to gain a deeper understanding of the effect of aging on the society that will pave the way to the development of new programs and policies to face the challenge of the aging society.